PROCESS FOR PREPARING CARBOXYLIC ACID DERIVATIVES

摘要

Title compds. (I)[Z=C or N; R=H or F are prepd. and showed effective bactericidal activities. Thus, m-phenylenediamine is reacted with EtOCH; (LCO2Et2) to give 3-H2NC6H4NHCH:C(CO2Et)2, which is heated with Ac2O Ph2O to produce quinelines (II). Compd. (II) was treated with EtBr and NaOH and then with 2,5dimethoxytetrahydrofuran in HoAc to give (I) (Z=CH, R=H).