发明名称 |
PHARMACEUTICAL FORMULATION FOR INCREASING SOLUBILITY OF 10-HYDROXYCAMPTOTHECIN COMPOUNDS IN NON-AQUEOUS POLAR SOLVENTS |
摘要 |
<p>The present invention relates to a pharmaceutical formulation for increasing the solubility of a 10-hydroxycamptothecin compound in non-aqueous polar solvent, comprising a 10-hydroxycamptothecin compound and an amine compound whose pK<SUB>a </SUB>value is 7.4 or more. By using the formulation according to the present invention, the solubility of the 10-hydroxycamptothecin compound for non-aqueous polar solvent is increased, while maintaining the active lactone form of 10-hydroxycamptothecin.</p> |
申请公布号 |
EP1824485(A1) |
申请公布日期 |
2007.08.29 |
申请号 |
EP20050823037 |
申请日期 |
2005.11.04 |
申请人 |
SAMYANG CORPORATION |
发明人 |
SEO, MIN-HYO;KANG, HYE-WON |
分类号 |
A61K31/475;A61K9/20;A61K47/18 |
主分类号 |
A61K31/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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