发明名称 |
TRICYCLIC OXAZEPINES AS IN VIVO IMAGING COMPOUNDS |
摘要 |
<p>Novel compounds of formula (I): suitable for use as in vivo imaging agents are provided as well as precursors suitable for the preparation of said compounds.The present invention also provides pharmaceuticals comprising the compounds and kits for the preparation of the pharmaceuticals. Furthermore, use of the compounds for imaging peripheral benzodiazepine receptors in a subject is provided, in particular for imaging pathological conditions in which PBR are upregulated, e.g. Parkinson's disease, multiple sclerosis, Alzheimer's disease and Huntington's disease, neuropathic pain, arthritis, asthma, atherosclerosis and cancer.</p> |
申请公布号 |
WO2007141491(A1) |
申请公布日期 |
2007.12.13 |
申请号 |
WO2007GB02024 |
申请日期 |
2007.05.31 |
申请人 |
HAMMERSMITH IMANET LIMITED;ARSTAD, ERIK;ROBINS, EDWARD, GEORGE;ZHAO, YOUGJUN |
发明人 |
ARSTAD, ERIK;ROBINS, EDWARD, GEORGE;ZHAO, YOUGJUN |
分类号 |
C07D498/04;A61K31/553 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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