发明名称 |
COMPOSITIONS COMPRISING LIPOXYGENASE INHIBITORS AND CYCLODEXTRIN |
摘要 |
The present invention is directed to formulations of inclusion complexes of lipoxygenase inhibitors and cyclodextrins having a therapeutically effective concentration of the lipoxygenase inhibitor, methods of making the same and methods of treating disease states using the same. Forming cyclodextrin complexes permits the enhancement of the aqueous solubility of lipoxygenase inhibitors which allows higher concentrations of the lipoxygenase in solution. Aqueous formulations of lipoxygenase inhibitors-cyclodextrin complexes are suitable for parenteral or oral administration for treating and/or preventing inflammatory disease states. The aqueous formulations can be lyophilized to prolong storage stability, assist in oral administration and/or provide for convenient and economical packaging.
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申请公布号 |
KR20080068136(A) |
申请公布日期 |
2008.07.22 |
申请号 |
KR20087014417 |
申请日期 |
2008.06.13 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A. |
发明人 |
KIPP JAMES E.;GUPTA PRAMOD |
分类号 |
A61K31/381;A61K31/343;A61K47/40;A61K47/48 |
主分类号 |
A61K31/381 |
代理机构 |
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