Vaccines against acquired immune deficiency syndrome

摘要

The invention relates to recombinant viruses which direct the expression of peptides or proteins similar to epitopes of the adenopathy virus LAV and human T lymphocyte leukaemia virus HTLV III, which is the causative agent of the acquired immunodeficiency syndrome AIDS. These viruses can be formulated in the form of vaccines containing live or inactivated viruses or in polyvalent vaccines for protecting against infection caused by LAV/HTLV III. Peptides and proteins similar to epitopes of this virus are also described. They can be prepared using recombinant DNA techniques or by chemical synthesis and used as immunogens in subunit vaccines or as antigens in diagnostic immunological assays.