CONSERVED MEMBRANE ACTIVATOR OF CALCINEURIN (CMAC), A NOVEL THERAPEUTIC PROTEIN AND TARGET
摘要
The invention discloses the first known function and biological activity of the hypothetical protein MGC14327, now designated cMAC, which is herein identified as an important controller of T-cell activation. It is contemplated herein that cMAC is a suitable drug target for the development of new therapeutics to treat cMAC-associated disorders. The invention relates to methods to treat said pathological conditions and to pharmaceutical compositions therefore. The pharmaceutical compositions comprise modulators with inhibitory or agonist effect on cMAC protein activity and/or cMAC gene expression. The invention also relates to methods to identify compounds with therapeutic usefulness to treat said pathological conditions, comprising identifying compounds that can inhibit or agonize cMAC protein activity and/or cMAC gene expression.
申请公布号
WO2007041513(A3)
申请公布日期
2007.09.20
申请号
WO2006US38482
申请日期
2006.10.02
申请人
NOVARTIS AG;NOVARTIS PHARMA GMBH;BITTINGER, MARK;CHOW, CHRISTINE;GUERINI, DANILO;LABOW, MARK ARON;LATARIO, BRIAN JUDE;XIONG, ZHAO-HUI
发明人
BITTINGER, MARK;CHOW, CHRISTINE;GUERINI, DANILO;LABOW, MARK ARON;LATARIO, BRIAN JUDE;XIONG, ZHAO-HUI