| 发明名称 |
ANTI-IL-4 ANTIBODIES AND BISPECIFIC ANTIBODIES AND USES THEREOF |
| 摘要 |
The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same. |
| 申请公布号 |
US2016207995(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201514858251 |
申请日期 |
2015.09.18 |
| 申请人 |
Genentech, Inc. |
发明人 |
Yansura Daniel G.;Chiang Nancy Y.;Dennis Mark S.;Dillon Michael;Fuh Germaine G.;Nakamura Gerald R.;Spiess Christoph;Wu Lawren C.;Zhang Yin |
| 分类号 |
C07K16/24;A61K45/06;A61K39/395 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A multispecific antibody comprising an antigen-binding domain that comprises a first VH/VL unit that specifically binds IL-4 and a second VH/VL unit that specifically binds IL-13, wherein the antibody:
a) inhibits binding of IL-4 to IL-4 receptor alpha (IL-4Rα), b) inhibits IL-4-induced proliferation of cells in vitro, and/or c) inhibits IL-13-induced proliferation of cells in vitro. |
| 地址 |
South San Francisco CA US |
