DRUG FOR PREVENTION AND THERAPY OF ISCHEMIC HEART DISEASE

摘要

PURPOSE:To obtain the subject drug for prevention and thereby of ischemic heart diseases such as angina and myocardial infraction by mixing an antibody having an inhibitory effect on activities of endoserines. CONSTITUTION:An antibody having a specific inhibitory effect on actions of endoserines such as contraction activity of mammal aorta vascular smooth muscles and cytotoxicity activities is mixed in. As the above-mentioned antibody, one belonging to either class of IgG, IgA and IgM may be used and an Fab' or Fab fraction prepared by removing Fc or Fc fragment therefrom or a polymer thereof may be used. In the endoserines endoserine-1 found in a supernatant of a cultured material of endothelial cells and having an amino acid sequence of formula I, endoserine-2 of formula II which sequence is decided from the chromosomal DNA as its gene family, endoserine-3 of formula III and human big-endoseine-1 of formula IV which is a precursor of endoserine-1 are included. The above-mentioned antibody is preferably administrated by intravenous injection 1-3 times a day in a daily does of 0.01-20mg, especially 0.1-5mg/kg/dosing.