Chromatography fractionating in batch processing uses a mathematical model to give on-line optimizing and parameter estimation to approximate and monitor the internal conditions in the chromatography column

摘要

The on-line technique to optimize batch chromatography processes, and estimate the parameters, shows the process as a mathematical model. The significant parameters of the model are estimated from the data of the detector at the outlet of the fractionating column. The best economical process operating parameter is determined in a two-stage on-line method, for a given product specification. The on-line technique to optimize batch chromatography processes, and estimate the parameters, shows the process as a mathematical model. The significant parameters of the model are estimated from the data of the detector at the outlet of the fractionating column. The best economical process operating parameter is determined in a two-stage on-line method, for a given product specification. The best economic process operating parameter is also determined by a two-stage technique. In addition, through measurements used with the aid of the model, the evident internal conditions of the chromatography column can be approximated and monitored. A set of permissible operating parameters is determined in a single-stage method for a given product specification and, in addition, through measurements used with the aid of the model, the evident internal conditions of the chromatography column can be approximated and monitored.