HYDROXYPROPYLAMIDE PEPTIDOMIMETICS AS INHIBITORS OF ASPARTYL PROTEASES

摘要

Compounds of Formula (I) are disclosed as inhibitors having activity against the aspartly proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula (I), Y is a heterocycle, amide, sulfonamide or carbamate and Z is an acyl or a functionalized acyl. Intermediates in the solid phase synthesis of compounds of Formula (I), in which compounds are attached to a solid phase support, are also disclosed.