NEW COMPOUNDS

摘要

The invention provides compounds of the formula I wherein Q is aryl or heterocyclyl any of which is optionally substituted; Z is O, S, NRa or S(=O)<SUB>p</SUB>; Y is NH, NHNH, CH<SUB>2</SUB>NH, O, S or S(=O)<SUB>p</SUB>; n is 0, 1, 2 or 3; m is 0, 1 or 2; p is 1 or 2; Ra is H or C<SUB>1</SUB>-C<SUB>4</SUB>alkyl; R<SUP>1</SUP> is hydrogen, C<SUB>1</SUB>-C<SUB>6</SUB>alkyl, C<SUB>0</SUB>-C<SUB>3</SUB>alkanediylC<SUB>3</SUB>-C<SUB>7</SUB>cycloalkyl, C<SUB>0</SUB>-C<SUB>3</SUB>alkanediylaryl or C<SUB>0</SUB>- C3alkanediylheterocyclyl; R<SUP>2</SUP> is hydrogen or C<SUB>1</SUB>-C<SUB>6</SUB>alkyl; X' is hydrogen, fluoro, hydroxy, amino or C<SUB>1</SUB>-C<SUB>6</SUB>alkoxy; X" is hydrogen, or when X' is fluoro, then X" may also be fluoro; R<SUP>3</SUP>is C<SUB>1</SUB>-C<SUB>6</SUB>alkyl; R<SUP>4'</SUP> is C<SUB>1</SUB>-C<SUB>6</SUB>alkyl; R<SUP>4"</SUP> is H or C<SUB>1</SUB>-C<SUB>6</SUB>alkyl; or R<SUP>4'</SUP> and R<SUP>4"</SUP> together with the carbon atom to which they are attached define a C<SUB>3</SUB>-C<SUB>6</SUB>cycloalkyl; W is C<SUB>1</SUB>-C<SUB>6</SUB>alkyl, C<SUB>3</SUB>-C<SUB>7</SUB>cycloalkyl, aryl or heterocyclyl any of which is optionally substituted; or a pharmaceutically acceptable salt, hydrate or N-oxide thereof. The compounds of the invention are inhibitors of aspartyl proteases such as renin and are among other things useful for the treatment of conditions associated with activities of the RAS, such as hypertension, heart failure and renal insufficiency.