| 主权项 |
1. A method for increasing the lifetime of red blood cells (RBCs) in need thereof comprising contacting blood with an effective amount of (1) a compound of formula I or a pharmaceutically acceptable salt thereof; (2) a composition comprising a compound of formula I or a salt thereof, and a carrier or (3) a pharmaceutically acceptable composition comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein: A is aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted, and the aryl or heteroaryl is optionally fused to an optionally substituted carbocyclyl or an optionally substituted heterocyclyl; X is selected from —NH—S(O)2—, —N(alkyl)-S(O)2—, —S(O)2—N(H)—, and —S(O)2—N(alkyl)-; R1a is selected from hydrogen, alkyl, and arylalkyl; and R1b is selected from OR3, N(alkyl)R3 and NHR3; or R1a is alken-1-yl and R1b is absent; each R2 is independently selected from halo, haloalkyl, alkyl, alkoxy and hydroxyl; R3 is selected from hydrogen, alkyl, optionally substituted aryl, optionally substituted heteroaryl, arylalkyl, C(O)Ra, and C(O)N(H)Ra, wherein Ra is selected from alkyl, alkenyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; and wherein any aryl or heteroaryl portion of Ra is optionally substituted; each R4 is independently selected from haloalkyl, alkyl, alkoxy and hydroxyl; n is 0, 1, or 2; and m is 0, 1, or 2. |
