Methods and compositions to modulate RNA processing

摘要

The present disclosure provides methods and compositions to selectively modulate RNA processing. The methods and compositions selectively enhance or repress RNA processing by up- or down-regulating Drosha expression and/or by providing RNA sequences with mis-matches introduced or removed 5 and/or 9-12 nucleotide positions from the Drosha cutting site. Therapeutic uses of the methods and compositions are also described.

主权项

1. An expression vector encoding an endogenous RNA nucleic acid molecule altered to remove at least one naturally-encoded mis-match at nucleotide position 5, 9, 10, 11 or 12 from the RNA's Drosha cutting site.