摘要 |
The invention is concerned with a new process for the preparation 1. Method for the manufacture of compounds of formula (see fig.I) wherein R is hydrogen, lower alkyl, lower alkoxy, cycloalkyl, cyclo-alkenyl, cycloalkyl-lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl-lower alkyl, heterocyclyl or heterocyclyl-lower alkyl; the lower alkyl, cycloalkyl, lower alkenyl, cycloalkenyl, lower alkynyl, aryl-lower alkyl, aryl and the heterocyclyl moieties being unsubstituted or substituted with at least one group selected from carboxy, amino, carbamoyl, nitro, cyano, lower alkyl, lower alkoxy, hydroxy, halogen, and it is further concerned with the use of compounds prepared according to above mentioned process for the preparation of cephem, isocephem and carbacephem derivatives. |