| 摘要 |
2,4-Disubstituted thiazole compounds of the formula <IMAGE> (I) or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, or X is S and Y is CH; R1 is certain straight or branched chain alkyl groups, (R3)2C6H3, or (R3)2Ar(CH2)n where n is an integer from 1 to 4, R3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups; R2 is H or (C1-C4)alkyl; or R1 and R2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and R4 is H, (C1-C5)alkyl, NH2 or CH2OH; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds. |
