Pharmaceutical compositions for combination therapy

摘要

This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

主权项

1. A method of reducing food intake by a human comprising:
administering to the human, 0.1 mg to 1 mg of Tesofensine, or a pharmaceutically acceptable salt thereof, daily in combination with 0.25 mg to 200 mg of Metoprolol, or a pharmaceutically acceptable salt thereof, daily wherein the combination is effective in reducing the food intake by the human and wherein the combination is effective in preventing or alleviating drug-induced cardiovascular side-effects.