VIRUS PREPARATIONS AND METHODS

摘要

Herpesvirus preparations, e.g. cultured HSV type 2, e.g. genetically disabled virus for vaccine use, can be purified, e.g. for subsequent pharmaceutical formulation, with solid phase affinity reagents containing sulphate- or sulphonate-comprising binding groups, e.g. sulphated polysaccharide groups, e.g. heparin or dextran sulphate, and eluting e.g. with salt solutions. The process can be combined with other culture and harvesting steps.