| 发明名称 |
METHOD OF TREATING RESTENOSIS BY ANTISENSE TARGETING OF C-MYC |
| 摘要 |
The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel antisense compounds and compositions, and a method for assaying the effectiveness of antisense delivery and uptake to a target vessel region. |
| 申请公布号 |
CA2359317(A1) |
申请公布日期 |
2000.08.03 |
| 申请号 |
CA20002359317 |
申请日期 |
2000.01.29 |
| 申请人 |
AVI BIOPHARMA, INC. |
发明人 |
IVERSEN, PATRICK L.;WELLER, DWIGHT D. |
| 分类号 |
G01N33/493;A61K9/127;A61K31/7088;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61K49/00;A61N1/30;A61P9/14;A61P11/00;A61P25/14;A61P31/12;A61P35/00;C12N15/09;C12N15/113;C12Q1/68;C12Q1/70;G01N33/53;G01N33/566;(IPC1-7):C12N15/11;C07K14/00;A61K47/48 |
主分类号 |
G01N33/493 |
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