发明名称 |
INHIBITORS OF THE ENZYMATIC ACTIVITY OF PSA |
摘要 |
This invention is directed to novel azetidinone compounds, to certain intermediates and processes for preparing these azetidinone compounds, and to formulations containing the same. The present invention also relates to the use of these azetidinones as inhibitors of the enzymatic activity of ProstateSpecific Antigen (PSA) as well as for treating prostatic cancer (Pca), Pca metastasis, benign prostatic hyperplasia (BPH) and breast cancer (Bc). Another aspect of the invention relates to inventive methods for treating Pca, Pca metastasis, BPH and Bc by administering any PSA inhibiting compound.
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申请公布号 |
CA2274958(A1) |
申请公布日期 |
1998.06.18 |
申请号 |
CA19972274958 |
申请日期 |
1997.12.09 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
ZHANG, TONY YANTAO;BECKER, GERALD WAYNE;ANDERSON, BENJAMIN ALAN;RIZZO, JOHN ROBERT;HARN, NANCY KAY;HATFIELD, LOWELL DELOSS;NEUBAUER, BLAKE LEE;CARTY, JAMES ALAN |
分类号 |
A61K31/00;A61K31/397;A61K31/4035;A61K31/422;A61K31/423;A61K31/427;A61K31/4427;A61K31/4439;A61K31/4709;A61K31/506;A61K31/517;A61K31/53;A61P13/08;A61P35/00;A61P35/04;A61P43/00;C07D205/08;C07D401/06;C07D401/14;C07D403/04;C07D403/14;C07D413/04;C07D413/14;(IPC1-7):C07D205/04;A61K31/43;A61K31/545 |
主分类号 |
A61K31/00 |
代理机构 |
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地址 |
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