发明名称 |
Novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
摘要 |
The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of formula (I), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis. |
申请公布号 |
AU709215(B2) |
申请公布日期 |
1999.08.26 |
申请号 |
AU19970022707 |
申请日期 |
1997.01.27 |
申请人 |
HOECHST MARION ROUSSEL, INC. |
发明人 |
GEORGE D MAYNARD;JOHN M. KANE;LARRY D BRATTON;ELIZABETH M KUDLACZ |
分类号 |
A61K31/445;A61K31/454;A61K31/4545;A61K31/5377;A61P1/04;A61P1/08;A61P11/06;A61P27/16;A61P37/08;A61P43/00;C07D211/22;C07D211/70;C07D401/04;C07D401/06;C07D401/14;C07D405/14;C07D409/14;C07D417/06;(IPC1-7):C07D401/14 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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