| 摘要 |
The invention relates to the use of a compound for the preparation of a medicament for the treatment of latent tuberculosis. The compound has the formula or It can be a pharmaceutically acceptable acid or base adjunctive salt, N-oxide, their tautomeric or stereochemical isomeric form. In the formulae R1 is hydrogen, halogen, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkoxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p has the value of 1, 2, 3 or 4; R2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino, or radical with the formula R3 is alkyl, Ar-alkyl, Het or Het-alkyl; q has the value of 0, 1, 2, 3 or 4; each R4 and R5 is independently hydrogen, alkyl or benzyl; or R4 and R5 can be taken together, including the nitrogento which they are attached; R6 is hydrogen, halogen, haloalkyl, hydroxy, Ar, alkyl, alkoxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl, or di(Ar)alkyl; or two adjacent R6 radicals can be taken together in order to form a two-valent radical -CH=CH-CH=CH- r has the value of 1, 2, 3,4 or 5; R7 is hydrogen, alkyl, Ar or Het; R8 is hydrogen or alkyl; R9 is oxo; R8 and R9 together form the radical =N-CH=CH-. |
