Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof

摘要

The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

主权项

1. A method for diagnosing a human as having an increased risk for psoriasis and alleviating the increased risk, the method comprising:
a) amplifying a fragment of nucleic acid from said human that includes polymorphism rs1422878 as represented by position 101 of SEQ ID NO:78 or its complement to thereby create an amplicon containing said polymorphism; b) testing for said polymorphism rs1422878 by contacting said amplicon with an oligonucleotide that selectively hybridizes to C at said position 101 of SEQ NO:78 or G at said complement; c) detecting the presence of said C or said G; d) diagnosing said human as having an increased risk for psoriasis; and e) administering an anti-IL-12p40 antibody to said human to thereby alleviate said increased risk for psoriasis.