| 发明名称 |
Methods of Making and Using Thioxothiazolidine and Rhodanine Derivatives as HIV-1 and JSP-1 Inhibitors |
| 摘要 |
The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity. |
| 申请公布号 |
US2016250194(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201615059018 |
申请日期 |
2016.03.02 |
| 申请人 |
Southern Methodist University ;The Johns Hopkins University |
发明人 |
Biehl Edward R.;Kamila Sukanta;Dawson Ted M. |
| 分类号 |
A61K31/427 |
主分类号 |
A61K31/427 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of reducing the activity of one or more enzymes comprising the steps of:
contacting the one or more enzymes with a thioxothiazolidin compound having a 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one skeleton to reduce the activity of the one or more enzymes, wherein the one or more enzymes are HIV-1 or JNK-stimulating phosphatase-1 (JSP-1) enzymes or both. |
| 地址 |
Dallas TX US |
