发明名称 |
TRANSCRIPTION FACTOR E2F DNA-BINDING DOMAIN INHIBITOR PEPTIDES AND THEIR USE |
摘要 |
The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.
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申请公布号 |
CA2359043(A1) |
申请公布日期 |
2000.08.03 |
申请号 |
CA20002359043 |
申请日期 |
2000.01.26 |
申请人 |
PROLIFIX LIMITED |
发明人 |
KONTERMANN, ROLAND ERNST;MONTIGIANI, SILVIA;MULLER, ROLF |
分类号 |
A61K38/00;C07K7/06;C07K7/08;C07K14/47;C12N5/02;(IPC1-7):C07K7/06;A61K38/08;A61K38/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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