The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced by the methods.
申请公布号
WO0070037(A3)
申请公布日期
2001.03.15
申请号
WO2000US13337
申请日期
2000.05.15
申请人
GENENCOR INTERNATIONAL, INC.
发明人
SCHELLENBERGER, VOLKER;LIU, AMY, D.;SELIFONOVA, OLGA, V.
