AMINOAMIDES AS OREXIN ANTAGONISTS

摘要

The present invention relates to compounds of formula (I) wherein Ar¹, Ar² and Ar³ are independently from each other unsubstituted or substituted aryl or heteroaryl; R¹, R² and R³ are independently from each other hydroxy, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano, 3-hydroxy-oxetan-3-yl, SO₂ -lower alkyl or di-lower alkyl amino; R⁴ /R⁵ are independently from each other hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, -(CH₂)_o-O-lower alkyl, -(CH₂)_o-N-(lower alkyl)₂, (CH₂)_p-cycloalkyl, (CH₂)_p-aryl, which aryl ring may be substituted by halogen, or R⁴ and R⁵ may form together with the N-atom to which they are attached a heterocyclic ring, optionally with further ring-heteroatoms selected from N, O or S; R⁶ is hydrogen or lower alkyl; R⁷ is hydrogen or lower alkyl; R⁸ is hydrogen or cyano; n is 0, 1, 2 or 3; o is 1, 2 or 3; p is 0, 1 or 2; or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. It has been found that the compounds of formula (I) are orexin receptor antagonists and the related compounds may be useful in the treatment of disorders, in which orexin pathways are involved like sleep disorders.