Methods and compositions for the rapid synthesis of radiometal-labeled probes

摘要

The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled probes, and methods of using the radiometal-labeled probes. Such radiometal-labeled probes can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT), and therapy studies.

主权项

1. A compound according to Formula III: wherein L is bound to any of the nitrogen atoms of the triazole moiety, wherein L comprises a peptide, the moiety M comprises a moiety selected from the group consisting of one or more polyethylene glycol units and one or more sugars, the moiety Q comprises a hexaazamacrobicyclic sarcophagine chelator capable of coordinating a radiometal nuclide, and the benzene rings may be mono-, di-, tri-, or tetra-substituted with R1 and R2 groups selected from the group consisting of H, halide, hydroxy, alkyl, aryl, nitro or amine groups.