发明名称 |
AMIDO-THIOPHENE COMPOUNDS AND THEIR USE |
摘要 |
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11 .beta.-hydroxysteroid dehydrogenase type 1(11 .beta.-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11 .beta.-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 .beta.-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc. |
申请公布号 |
CA2716679(C) |
申请公布日期 |
2016.07.12 |
申请号 |
CA20092716679 |
申请日期 |
2009.03.13 |
申请人 |
THE UNIVERSITY OF EDINBURGH |
发明人 |
WEBSTER, SCOTT PETER;SECKL, JONATHAN ROBERT;WALKER, BRIAN ROBERT;WARD, PETER;PALLIN, THOMAS DAVID;DYKE, HAZEL JOAN;PERRIOR, TREVOR ROBERT |
分类号 |
C07D333/38;A61K31/381;C07D409/04;C07D409/06;C07D409/14;C07D413/06;C07D413/14;C07D417/14;C07D471/04;C07D487/04;C07D491/04 |
主分类号 |
C07D333/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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