| 发明名称 |
DIKETOACID-DERIVATIVES AS INHIBITORS OF POLYMERASES |
| 摘要 |
Diketoacids of Formula (A) are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse transcriptase of human immunodeficiency virus (HIV RT). The group R may be broadly chosen and is an organic moiety which contains 2 to 24 carbon atoms and includes an optionall y cyclic or heterocyclic group in which the atom directly bonded to the adjace nt carbonyl in the diketoacid is part of the ring structure.
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| 申请公布号 |
CA2338490(A1) |
申请公布日期 |
2000.02.10 |
| 申请号 |
CA19992338490 |
申请日期 |
1999.07.27 |
| 申请人 |
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
KOCH, UWE;TOMEI, LICIA;ALTAMURA, SERGIO;NEUNER, PHILIPPE JEAN SIEGFRIED;SUMMA, VINCENZO |
| 分类号 |
C07D295/10;A61K31/192;A61K31/195;A61K31/216;A61K31/27;A61K31/275;A61K31/343;A61K31/381;A61K31/40;A61K31/4025;A61K31/4184;A61K31/4192;A61K31/42;A61K31/4406;A61K31/4427;A61K31/4433;A61K31/4436;A61K31/445;A61K31/451;A61K31/4535;A61K31/454;A61K31/4709;A61K31/4725;A61P31/12;A61P43/00;C07C59/76;C07C59/84;C07C59/86;C07C59/90;C07C65/40;C07C229/42;C07C233/56;C07C255/13;C07C255/54;C07C255/57;C07C271/28;C07C275/42;C07C311/08;C07C311/13;C07C311/21;C07C323/62;C07D207/32;C07D207/337;C07D211/34;C07D211/96;C07D213/30;C07D213/89;C07D235/10;C07D249/18;C07D249/20;C07D261/08;C07D261/12;C07D307/80;C07D333/24;C07D333/28;C07D333/32;C07D333/34;C07D333/36;C07D333/38;C07D333/40;C07D333/60;C07D333/74;C07D401/12;C07D409/04;C07D495/04;(IPC1-7):C07C59/76;C07D333/04;A61K31/19;C07D207/30;A61K31/335;C07D307/34;A61K31/38 |
主分类号 |
C07D295/10 |
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