发明名称 |
Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases |
摘要 |
Processes of preparing pharmaceutical compositions comprising 3-(6-(1-(2,2- difluorobenzo[d][1,3] dioxol-5 -yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5- hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-lH-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of administering, and kits thereof are disclosed. |
申请公布号 |
AU2014349010(A1) |
申请公布日期 |
2016.06.30 |
申请号 |
AU20140349010 |
申请日期 |
2014.10.31 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
SWINNEY, KELLY ANN;HURTER, PATRICIA NELL;NADIG, DAVID E.;SMITH, DAVID;THOMAS, VANCE HAYDEN;WARMAN, MARTIN PAUL |
分类号 |
A61K31/435;A61K31/44;A61K31/47;A61P43/00 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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