发明名称 METHOD SYNTHESIZING PHARMACEUTICAL INTERMEDIATE PHENANTHRENE COMPOUND IN SODIUM HYDROXIDE ENVIRONMENT
摘要 The present invention relates to a method synthesizing a phenanthrene compound in a sodium hydroxide environment, wherein the phenanthrene compound is presented by formula (I). The method comprises: under an inert gas environment, when a catalyst, an organic ligand, and sodium hydroxide are present, a formula (II) compound and formula (III) compound undergo a reaction in a solvent to obtain a formula (I) compound, wherein R1 and R2 are independently an H, a C1-C6 alkyl, a C1-C6 alkyloxy or a halogen. R3 is a C6-C10 aryl or a C5-C8 heteroaryl optionally substituted with 1 to 3 substituent groups, and the substituent groups are a C1-C6 alkyl or halogen. The method obtains a good effect by selecting a suitable catalyst, organic ligand, and base and solvent, and has a wide prospect for industrial applications.
申请公布号 WO2016141840(A1) 申请公布日期 2016.09.15
申请号 WO2016CN75446 申请日期 2016.03.03
申请人 WANG, Nengqing 发明人 ZHAI, Xueyan
分类号 C07B37/10;C07C2/42;C07C15/30;C07C17/275;C07C25/22;C07D213/127;C07D213/16 主分类号 C07B37/10
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