Bone treatment systems and methods

摘要

The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.

主权项

1. A bone cement system, comprising:
a pre-mixture comprising:
a first monomer-carrying component; anda second polymer-carrying component, separate from the first monomer-carrying component, the second polymer-carrying component comprising a plurality of bead populations that have different mean particle sizes and an initiator in different amounts, the second polymer-carrying component comprising:
a first polymer bead population having a first mean particle size and including the initiator at a first weight percent of the first polymer bead population, wherein the initiator is integrated throughout the volume of each of the first polymer beads;a second polymer bead population having a second mean particle size smaller than the first mean particle size and including the initiator at a second weight percent of the second polymer bead population that is higher than the first weight percent, wherein the initiator is integrated throughout the volume of each of the second polymer; anda third polymer bead population having a third mean particle size smaller than the second mean particle size and including an initiator at a third weight percent of the third polymer bead population that is lower than the first weight percent,wherein upon forming a mixture of the first monomer-carrying component and the second polymer-carrying component, different dissolution rates and the different initiator amounts of the plurality of bead populations control an availability of the initiator in the mixture that is sufficiently low and slow-varying over time, such that the temperature of the mixture remains below 75° C. and, after an initial exposure period post-mixing, a time-viscosity curve slope remains less than or equal to about 200 Pa·s/minute until the mixture reaches a viscosity of about 2500 Pa·s.