发明名称 |
Vinyl ether lipids with cleavable hydrophilic headgroups |
摘要 |
A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with target lipid membranes. The cleavable vinyl ether linkage allows the hydrophilic headgroup to be dissociated from the hydrophobic tailgroup(s) of the lipid compound to facilitate phase transitions in the lipid bilayer. |
申请公布号 |
AU6105300(A) |
申请公布日期 |
2001.02.05 |
申请号 |
AU20000061053 |
申请日期 |
2000.07.17 |
申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
DAVID H THOMPSON;JEREMY A. BOOMER;ROBERT HAYNES |
分类号 |
A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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