FLUORINATED PROSTAGLANDIN DERIVATIVES AND MEDICINES

摘要

Fluorinated prostaglandin derivatives represented by general formula (1) or salts thereof; and medicines containing the same as the active ingredient, particularly ones to be used for preventing or treating eye diseases. In said formula A represents vinylene, ethylene, ethynylene, etc.; R<1> represents aryloxyalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, etc.; R<2> and R<3> represent each hydrogen, acyl, etc.; Z represents -OR<4>, -NHCOR<5>, -NHSO2R<6>, -SR<7> (wherein R<4>, R<5>, R<6> and R<7> represent each hydrogen, alkyl, etc.); and the combination of the solid line with the broken line represents a single bond, a cis double bond or a trans double bond. The medicines are excellent as a medicine for eye diseases with high pharmacological effects and low side effects.