摘要 |
<p>Cyclic peptide antibiotic A-21978C deriv. (I) and their salts are new (where R is H, 90-methyldecanoyl, the specific C10 alkanoyl gp. of A- 21978C0, an aminoacyl gp. -CO- Q-NH2 or N-alkanoylamino gp. -W-CO-R2; Q is C1-16 alkylene, W is -CO-A-NH gp. A is C1-10 alkylene; R3 is hydroxymentyl; X is H, Cl, Br, carbamyl; X1 is Cl, Br, I, amino; B is -(CH2)n-, -CH/CH- or -CH2NHCO-; n is 1 to 3; R2 is C1-17 alkyl; R1 is H or aminoacyl gp. (I) are antibacterial agents and inters for these.</p> |