| 发明名称 | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D<sub>3 </sub>analogs | ||
| 摘要 | Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitamin D3 compounds, their biological activities, and various pharmaceutical uses for these compounds. Particularly disclosed are (22E)-(24R)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 and (22E)-(24S)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds. | ||
| 申请公布号 | US9416102(B2) | 申请公布日期 | 2016.08.16 |
| 申请号 | US201314084281 | 申请日期 | 2013.11.19 |
| 申请人 | Wisconsin Alumni Research Foundation | 发明人 | DeLuca Hector F.;Plum Lori A.;Barycki Rafal;Clagett-Dame Margaret |
| 分类号 | A61K31/593;C07C401/00;A61K31/592 | 主分类号 | A61K31/593 |
| 代理机构 | Andrus Intellectual Property Law, LLP | 代理人 | Andrus Intellectual Property Law, LLP |
| 主权项 | 1. A compound of the formula: where X1, X2, X3, and X4, which are the same or different, are each selected from hydrogen or a hydroxy-protecting group. | ||
| 地址 | Madison WI US | ||