| 主权项 |
1. An isolated nucleic acid encoding the amino acid sequence of an IL-1β binding protein comprising an antigen binding domain, said binding protein capable of binding human IL-1β, said antigen binding domain comprising six CDRs: CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, as defined below:(SEQ ID NO: 190)CDR-H1: X1-Y-D-M-S, wherein;X1 is K or R;(SEQ ID NO: 191)CDR-H2: Y-X2-S-X4-G-G-X7-G-T-Y-Y-P-D-X14-X15-K-G,wherein;X2 is I or V;X4 is S or H;X7 is G or A;X14 is T or S;andX15 is V or A;(SEQ ID NO: 192)CDR-H3: G-G-V-X4-K-G-X7-F-D-X10,wherein;X4 is T or Y;X7 is Y or C;andX10 is V, E, L, M, Q, or Y;(SEQ ID NO: 193)CDR-L1: R-A-S-G-N-I-X7-X8-X9-L-X11,wherein;X7 is H, Y, or W;X8 is N, G, T, Q, E, H, D, or K;X9 is Y or W;andX11 is T, A, or N;(SEQ ID NO: 194)CDR-L2: X1-A-K-X4-L-X6-X7,wherein;X1 is N, Q, or D;X4 is T, N, I, E, or S;X6 is A, M, or E; andX7 is D, E, S, or A;and(SEQ ID NO: 195)CDR-L3: Q-X2-F-W-X5-X6-P-X8-X9,wherein;X2 is H or Q;X5 is S, N, T, K, R, or M;X6 is I or L;X8 is Y or A;andX9 is T, I, and N;except that(SEQ ID NO: 18)CDR-H2 cannot be Y-I-S-S-G-G-G-G-T-Y-Y-P-D-T-V-K-G;(SEQ ID NO: 19)CDR-H3 cannot be G-G-V-T-K-G-Y-F-D-V;(SEQ ID NO: 20)CDR-L1 cannot be R-A-S-G-N-I-H-N-Y-L-T;(SEQ ID NO: 21)CDR-L2 cannot be N-A-K-T-L-A-D; and(SEQ ID NO: 22)CDR-L3 cannot be Q-H-F-W-S-I-P-Y-T. |
