1,3,4-SUBSTITUTED DERIVATIVE AND BICYCLIC DERIVATIVE OF 2-AZETIDINONE AND THEIR PRODUCTION

摘要

The invention provides 1,3,4 substituted and bicyclic derivatives of 2-azetidinones of the formula wherein R is an amino group, a protected amino group, or a group of the formula -NRR, wherein R is an amino protecting group and R is selected from the group consisting of acryloyl or substituted acryloyl; R<1> is hydrogen or an amide protecting group; R<2> is a radical forming group; A is -S- or -(SO)n-, wherein n is 0 or 1; and B and C are independently selected from a group consisting of oxygen, sulfur, methylene, selenium, and nitrogen. These compounds are valuable intermediates useful in the preparation of 1-carba(dethia)cephalosporin antibiotics.