Method for the production of 1-amino-3-phenyluracil derivatives

摘要

The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the formula (II) in which R¹ is hydrogen, cyano, nitro or halogen, R² is cyano, nitro, halogen or optionally substituted alkyl or alkoxy, R³ is hydrogen, hydroxyl, mercapto, amino, hydroxyamino, hydrazino, halogen, or one of the radicals -R⁶, -Q-R⁶, -NH-R⁶, -NH-O-R⁶, -NH-SO₂-R⁶, -N(SO₂-R⁶)₂, -CQ¹-R⁶, -CQ¹-Q²-R⁶, -CQ¹-NH-R⁶, -Q²-CQ¹-R⁶, -NH-CQ¹-R⁶, -N(SO₂-R⁶)(CQ¹-R⁶), -Q²-CQ¹-Q²-R⁶, -NH-CQ¹-Q²-R⁶ or -Q²-CQ¹-NH-R⁶, where Q is O, S, SO or SO₂, Q¹ and Q² are each independently oxygen or sulphur and R⁶ is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, R⁴ is hydrogen, halogen or optionally substituted alkyl, and R⁵ is fluorine- and/or chlorine-substituted alkyl, as intermediates for the 1-amino-3-phenyluracil derivatives, and to a process for preparing the intermediates.