| 摘要 |
Aminobenzimidazoles and benzimidazoles having inhibitory activity on RSV replication and having the formula the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, wherein G is a direct bond or C<SUB>1-10</SUB>alkanediyl optionally substituted with one or more hydroxy, C<SUB>1-6</SUB>alkyloxy, Ar<SUP>1</SUP>C<SUB>1-6</SUB>alkyloxy, C<SUB>1-6</SUB>alkylthio, Ar<SUP>1</SUP>C<SUB>1-6</SUB>alkylthio, HO(-CH<SUB>2</SUB>-CH<SUB>2</SUB>-O)<SUB>n</SUB>-, C<SUB>1-6</SUB>alkyloxy(-CH<SUB>2</SUB>-CH<SUB>2</SUB>-O)<SUB>n</SUB>- or Ar<SUP>1</SUP>C<SUB>1-6</SUB>alkyloxy(-CH<SUB>2</SUB>-CH<SUB>2</SUB>-O)<SUB>n</SUB>-; R<SUP>1 </SUP>is Ar<SUP>1 </SUP>or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di(C<SUB>1-4</SUB>alkyl)amino; one of R<SUP>2a </SUP>and R<SUP>3a </SUP>is selected from halo, optionally mono- or polysubstituted C<SUB>1-6</SUB>alkyl, optionally mono- or polysubstituted C<SUB>2-6</SUB>alkenyl, nitro, hydroxy, Ar<SUP>2</SUP>, N(R<SUP>4a</SUP>R<SUP>4b</SUP>), N(R<SUP>4a</SUP>R<SUP>4b</SUP>)sulfonyl, N(R<SUP>4a</SUP>R<SUP>4b</SUP>)carbonyl, C<SUB>1-6</SUB>alkyloxy, Ar<SUP>2</SUP>oxy, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyloxy, carboxyl, C<SUB>1-6</SUB>alkyloxycarbonyl, or -C(-Z)Ar<SUP>2</SUP>; and the other one of R<SUP>2a </SUP>and R<SUP>3a </SUP>is hydrogen; in case R<SUP>2a </SUP>is different from hydrogen then R<SUP>2b </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl or halogen and R<SUP>3b </SUP>is hydrogen; in case R<SUP>3a </SUP>is different from hydrogen then R<SUP>3b </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl or halogen and R<SUP>2b </SUP>is hydrogen. Compositions containg these compounds as active ingredient and processes for preparing these compounds and compositions.
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