| 发明名称 | Single domain antibodies directed against tumor necrosis factor-alpha and uses therefor | ||
| 摘要 | The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Tumor Necrosis Factor-alpha. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides. It further relates to protocols for screening for agents that modulate the TNF-alpha receptor, and the agents resulting from said screening. | ||
| 申请公布号 | US9371381(B2) | 申请公布日期 | 2016.06.21 |
| 申请号 | US201414529280 | 申请日期 | 2014.10.31 |
| 申请人 | Ablynx, N.V. | 发明人 | Silence Karen;Lauwereys Marc Jozef;De Haard Hans |
| 分类号 | C07K16/24;C07K16/18;C07K16/28;C07K16/36;C07K16/40;C07K16/42;A61K39/00 | 主分类号 | C07K16/24 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. An anti-TNF-alpha polypeptide comprising at least one anti-TNF-alpha single domain antibody comprising: (a) an amino acid sequence comprising SEQ ID NO: 1, or (b) an amino acid sequence with more than 85% identity to the amino acid sequence of SEQ ID NO: 1, and which comprises an arginine residue at position 103 (numbering according to Kabat). | ||
| 地址 | Zwijnaarde BE | ||