Macrocyclic indole derivatives useful as hepatitis C virus inhibitors

摘要

Inhibitors of HCV replication of formula (I);
including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1, R2, R4, R5, R6 and R7 have the meaning defined in the claims.
;The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.

主权项

1. A method for inhibiting HCV replication, comprising administering to a subject in need thereof a compound of Formula (I) or a stereochemically isomeric form, N-oxide, salt, hydrate, or solvate thereof, wherein:
R1 is a bivalent chain selected from each R3 is independently selected from the group comprising hydrogen, C1-4alkyl and C3-5cycloalkyl;a is 3, 4, 5 or 6;each b is independently 1 or 2;c is 1 or 2;macrocycle A has 14 to 18 member atoms;each R2 is independently hydrogen, halo or C1-4alkoxy;R4 and R5 are hydrogen or R4 and R5 together form a double bond or a methylene group to form a fused cyclopropyl;R6 is hydrogen or methyl; andR7 is a C3-7cycloalkyl optionally substituted with halo.