| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I [R<1> is (protected) OH; R<2> is H or (protected) OH; R<3> is methyl, ethyl, propyl or allyl; (n) is 1 or 2; the symbol of solid and dotted line indicates single bond or double bond]. EXAMPLE:17-Allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1- methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4- azatricyclo[22.3.1.0<4>,<9>]octacos-18-ene-2,3,10,16-tetraone. USE:An immunosuppressive agent. PREPARATION:A strain, such as Streptomyces tsukubaensis No.9993 (FERM P-7886), belonging to the genus Streptomyces is fermented or a hydroxy- protecting group is introduced into a compound expressed by formula II.</p> |
