| 发明名称 |
NT-3 AND BDNF ANALOGS HAVING IMPROVED CIRCULATING LIFE AND/OR ABSORPTION |
| 摘要 |
The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.
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| 申请公布号 |
CA2259163(A1) |
申请公布日期 |
1998.01.29 |
| 申请号 |
CA19972259163 |
申请日期 |
1997.07.17 |
| 申请人 |
AMGEN INC. |
发明人 |
HERSHENSON, SUSAN IRENE;CHEUNG, ELLEN NGOI YIN;YOUNG, JOHN DAVID;BOONE, THOMAS CHARLES |
| 分类号 |
A61K38/00;C07K14/475;C07K14/50;C07K14/54;(IPC1-7):C12N15/18;A61K38/18;C07K16/22;C07K14/48 |
主分类号 |
A61K38/00 |
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