发明名称 |
Viruses targeted to hypoxic cells and tissues |
摘要 |
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically engineered to have an hypoxia-responsive element, or a multiplicity of such elements, operably linked to a promoter which is operably linked to a gene or genes which regulate or modulate replication of the virus or encode a therapeutic molecule. The invention also includes constructs useful for screening for agents which interact with proteins or genes in the hypoxia-inducible pathway. |
申请公布号 |
AU9479301(A) |
申请公布日期 |
2002.04.08 |
申请号 |
AU20010094793 |
申请日期 |
2001.09.26 |
申请人 |
EMORY UNIVERSITY |
发明人 |
ERWIN VAN MEIR;AINSLEY C. NICHOLSON;DAWN E. POST |
分类号 |
C12N15/09;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C12N5/10;C12N7/00;C12N15/19;C12N15/33;C12N15/34;C12N15/861;C12Q1/02;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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