| 发明名称 |
Fusion proteins comprising DP-178 and other viral fusion inhibitor peptides useful for treating aids |
| 摘要 |
The present invention relates to fusion peptides which exhibit potent anti-retroviral activity. The fusion peptides of the invention comprise a macromolecular carrier group fused to a gp41-derived DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1<SUB>LA1 </SUB>gp41 protein, or fragments, analogs or homologs of DP178. The invention further relates to the uses of such fusion peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
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| 申请公布号 |
US2007202123(A1) |
申请公布日期 |
2007.08.30 |
| 申请号 |
US20050253274 |
申请日期 |
2005.10.17 |
| 申请人 |
DUKE UNIVERSITY |
发明人 |
GREENBERG MICHAEL L.;MATTHEWS THOMAS J.;CHEN CHIN-HO |
| 分类号 |
C12N15/09;C12Q1/68;A61K38/00;A61K39/00;A61K39/12;A61K39/145;A61K39/155;A61K39/21;A61K39/215;A61K39/245;A61K39/29;A61P31/12;A61P31/16;A61P31/18;C07K5/083;C07K5/087;C07K5/09;C07K5/093;C07K5/103;C07K5/107;C07K5/113;C07K5/117;C07K7/04;C07K14/005;C07K14/02;C07K14/025;C07K14/05;C07K14/11;C07K14/115;C07K14/12;C07K14/125;C07K14/13;C07K14/135;C07K14/15;C07K14/155;C07K14/16;C07K14/21;C07K14/22;C07K14/245;C07K14/285;C07K14/31;C12N9/94;C12N9/96;C12N9/98;C12N9/99;G01N33/50 |
主分类号 |
C12N15/09 |
| 代理机构 |
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