Nucleic acid compositions and methods of introducing nucleic acids into cells

摘要

Bifunctional nucleic acid molecules are disclosed which can bind to a cell surface and which comprise a first nucleic acid which comprises an aptamer bonded to a second nucleic acid, the biological effector sequence, that possesses a biological activity. Also contemplated are templates, vectors and host cells comprising the bifunctional nucleic acid molecules and methods for introducing the biological effector sequence into an organism by administering a host cell transfected with the biological effector sequence.