HEAT-RESISTANT ENZYME HAVING SUGAR NUCLEOTIDE SYNTHESIZING ACTIVITY AND DNA ENCODING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain a sugar nucleotide synthetase having heat-resistance and broad substrate specificity and to stably synthesize a sugar nucleotide useful as a substrate for sugar chain synthesis.

SOLUTION: A gene of the sugar nucleotide synthetase has been found from total genom gene information on a super-thermophilic archaebacteria, Sulfolobus tokodaii. The sugar nucleotide synthetase having heat-resistance and broad substrate specificity is produced by a genetic engineering means using the gene and the sugar nucleotide is stably synthesized by using the enzyme.

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