Cement products and methods of making and using the same

摘要

Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

主权项

1. An orthopedic cement product comprising:
a first component comprising a polymerizable resin that comprises two or more acrylate groups in combination with a second polymerizable resin comprising three or more acrylate groups; a second component comprising an aliphatic or aromatic polyamine having at least one secondary amine group selected from the group consisting of spermidine, spermine, diethylenetriamine, tetraethylenepentamine, pentaethylenehexamine, N-(3-aminopropyl)-1,3-propanediamine, and 2,6-diaminopurine; and a bioceramic filler selected from the group consisting of tricalcium phosphate, hydroxyapatite, calcium phosphate, or a combination thereof; wherein the first component and second component are capable of reacting with each other in a polymerization reaction to produce an orthopedic or dental cement, wherein when the first component and second component are reacted together in a polymerization reaction at room temperature and allowed to set at about 37° C., the reaction does not exceed a maximum temperature of 60° C. for a period of one minute; and wherein the cement product after setting has a compressive strength of about 20 MPa to about 250 MPa.