| 摘要 |
NEW MATERIAL:A compound (salt) expressed by formula I [R1 is H, lower alkyl or (protected) hydroxy lower alkyl; CO2R2 is (protected) carboxyl, etc.; R3 is formula II (Het is 5- or 6-membered heterocyclic ring containing O, S, N, etc.; R4 and R5 are H, halogen, alkyl, etc.)]. EXAMPLE:(5R,6S,8R)-2-[(6,7-Dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)thio ]-6-(1- hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid. USE:An antimicrobial agent. PREPARATION:For example, a carbapenem derivative expressed by formula III (R6 is hydrocarbon, etc.) is oxidized with an oxidizing agent to provide a sulfoxide derivative expressed by formula IV, which is then reacted with a nitrogen-containing heterocyclic thiol compound expressed by the formula R3SH to afford the compound expressed by formula I. |
